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Several groups have shown that, despite the loss of endothelial caveolae, Cav-1−/− mice show marked increases in microvascular paracellular albumin permeability, which is partly due to constitutive activation of endothelial NOS.

Compound Alb Cre, Mst1/Mst2 mutant mice show marked liver enlargement at 4 5 weeks age and require euthanisation by 4 5 months because of multiple large liver tumours.

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All control tissue sections showed background levels of staining while three out four poly(I∶C /5-BP mI∶C /5-BPd miceed increashowed TG2 activity (Figure 4C, Figure S2).

Pathological characterization of p23-ST1 mice showed marked astroglial and microglial reaction as well as a significant loss of neurons in septal areas (Fig. 8).

DLN cells obtained from CIA mice showed marked CII-specific proliferation and effector T cells producing high levels of Th1-type cytokines (IFN-γ, IL-2 and TNF-α) and low levels of Th2-type cytokines (IL-4 and IL-10) (Fig. 3A).

V617F-TG mice showed marked leukocytosis.

Similarly, livers of LS- G6pc−/− mice showed marked steatosis, inflammation and necrosis.

Female diabetic mice showed marked diastolic dysfunction within 8 weeks of STZ-induced diabetes in our study, however, this was lost at 12 weeks.

A study in mice showed marked urinary NGAL increase within 2 hours of renal injury, by far preceding conventional markers of AKI [ 9].

Jund-/ mice showed marked susceptibility to Crgn on day 10 after the induction of accelerated NTN when compared with age- and sex-matched WT littermates.

Muscle histology from end-stage hFUS mice showed marked grouped atrophy of muscle fibres characteristic of denervation seen in muscle from ALS patients (Fig.  8o).

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