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The MT-null mice show low concentration of Zn in skin, and the epidermis fails to exhibit hyperplasia [22].
Caveolin-1-null mice show low adiposity but otherwise present a relatively mild phenotype under normal conditions (Drab et al. 2001; Razani et al. 2002).
We initially found that Day 0 Wt mice show low levels of EC staining for Id1, which was elevated by Day 12.
As D1R KO mice show low body weight on standard diets and have a decreased interest in feeding (Drago et al., 1994), one possible explanation for their lack of FAA on a 60% CR diet consisting of standard chow (5001 rodent chow; LabDiet) is that it was insufficiently palatable to induce wakefulness that is a prerequisite for FAA.
Although osteoclasts in TRAF6-deficient mice are inactive, and the splenocytes of our IFN-γR KO mice show low levels of TRAF6, the osteoclasts derived from the splenocytes of both the IFN-γR KO mice and the wild-type mice were indeed active, as proved with the pit-forming assay.
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Tumors in vaccinated mice showed low levels of PSA expression and significant CD8+ T cell infiltration.
SeP deficient mice showed low level of selenium in brain, and short life span, rescued by a high selenium diet.
Moreover, freshly isolated splenocytes from WT mice showed low levels of IFN-γ producing cells at days 10 and 15 p.i., suggesting that the infection is cleared in the inoculation site, with low systemic immune activation (data not shown).
In contrast to wild-type mice with abundantly dispersed CD8+ T cells in the challenged ear MMP19−/− mice showed low numbers of T cells that were comparable to the unsensitized situation (Fig. 2E).
In contrast, rZH501-M847-G-infected mice showed low, but detectable levels of neutralizing antibodies early in infection; moreover, a low titer of neutralizing antibody was detected as early as 1 day p.i. in some of rZH501-M847-G-infected mice.
Similarly, un-treated fetal thymic organ cultures (FTOC) of K14CreERxRac1flox/flox mice showed low expression of c-Myc (17.9%±7.3; Supplementary Figure S2E), however K14CreERxRac1flox/flox derived FTOC in the presence of 4OHT resulted in up-regulation of c-Myc immunofluorescent nuclei (51.1%±8.4; p<0.05; Figure S2F).
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