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Cav-1/ApoE double-knockout mice show less lipid accumulation in the aorta, while the absence of Cav-1 promotes smooth muscle cells proliferation increasing intimal hyperplasia upon carotid injury [13]; [13].
Nectin knockout mice show less severe defects presumably because of compensation between the different isoforms.
Similarly, TLR2 and TLR 4 mice show less ozone-induced airway hyper-responsiveness and neutrophilia than wild-type mice [ 41].
Immune-deficient nude- mdx and scid-mdx mice show less fibrosis (Farini et al., 2007; Morrison et al., 2000).
Young female mdx mice show less myonecrosis and more fiber regeneration; mdx ovariectomized females show a reduction of fiber regeneration.
Interestingly, female rats and mice show less anxiety-like behavior and arousal in novel environments than males.
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Megalin-deficient mice showed less uptake in the renal cortex in autoradiography [24].
In mouse model of carotid artery endothelium injury, NR3-treated mice showed less tail bleeding time than AcAP5-treated mice, and aspirin plus NR3 treatment exhibited moderate reduction of blood loss compared with aspirin plus AcAP5 treatment.
Levels of the immune cells known as eosinophils, and of the antibody immunoglobulin E both usually increased in allergies and asthma were almost halved, and the mice showed less constriction of their airways.
These results indicate that DGKβ KO mice showed less anxiety.
All surviving mice showed less than 0.01% of Vβ14+ cells at day 200 (data not shown).
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CEO of Professional Science Editing for Scientists @ prosciediting.com