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TXNIP knock-out mice show high levels of accumulated inactive PTEN with higher levels of activated AKT resulting in more glycolytic oxidation in their skeletal muscle [94].
GFP+ Schwann cells purified from GFP mice show high susceptibility to ML infection.
Sera from normal MA mice show high levels of a natural antibody capable of neutralizing the virus.
Kidneys of nephritic NZM2328 mice show high levels of expression of Th1-type cytokines like IFN-γ and IL-12 [ 67].
Under light-dark conditions and ad libitum feeding, αMUPA mice show high amplitude, appropriately reset circadian rhythms in peripheral clock genes [ 194].
59 CRHR2− /− mice show high blood pressure and reduced sustained hypophagia; 49 thus CRHR2 variants may lead to high blood pressure and obesity of MetS, the latter potentially due to impaired mediation of food intake control.
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As observed in DM1 patients [4], dmpk−/− mice show higher concentrations of plasma insulin than wild-type mice in the glucose tolerance tests.
Clock mutant mice show higher number of mid gestation fetal reabsorption [28] and lower number of pups born when mice are kept under continuous darkness [29].
Since female mice show higher baseline hepcidin expression than males ([41]; Figure 9C), we used exclusively female littermates for the experiments.
Consistently, trpc1 −/− mice show higher IL-1β secretion in the sepsis model of intraperitoneal LPS injection.
In addition, trpc1 −/− mice show higher IL-1β secretion in their sera following LPS injection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com