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Thus, only a distinct subpopulation (i.e. the 'susceptible' mice) displays social avoidance and behavioural signs of anhedonia, while all exposed animals ('susceptible' and 'unsusceptible' mice) show elevated corticosterone levels and increased anxiety-like behaviour 31.
Sox2- Cre: Errβ lox / lox mice show elevated activity levels due to defects in vestibular system development [ 14, 26], which likely contribute to the body weight and body composition differences observed at nine months of age.
ApoE-deficient animals (which show a similar phenotype to Apoε4 allele carrying mice) show elevated inflammation and gliosis associated with their deficient phagocytosis of apoptotic bodies [ 73] and APP23 mice negative for ApoE fed an atherogenic diet also showed increased endothelial activation and increased vascular pro-inflammatory markers but no alteration in Aβ deposition [ 74].
Similarly, cultured mesangial cells from α1-null mice showed elevated expression levels of all three MMPs, whereas mesangial cells from Alport mice show elevated expression levels of only MMP-9.
As a matter of fact, TTP knocked-out mice show elevated levels of TNF-α production in response to LPS [12].
In fact, mouse embryonic fibroblasts (MEF) derived from Chfr knockout mice show elevated protein levels of Aurora A and display chromosome abnormalities [21].
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Analysis of α-SMA expression in wound sites by immunofluorescence revealed that GADD34−/− mice showed elevated α-SMA+ areas (relative to granulation tissue) 6 (P < 0.05), 8 (P < 0.05), and 12 days (P < 0.001) after wounding compared with WT mice; however, 16 days after wounding, α-SMA-expressing myofibroblasts completely disappeared from granulation tissues in both GADD34−/− and WT mice and 2(b)).
As expected, human and mouse NMIs show elevated CpG O/E and GC content compared to control regions of the genome.
In fact, under cold-acclimated conditions, mice lacking L-PGDS show elevated reliance on carbohydrate to provide fuel for thermogenesis and increased expression of genes regulating glycolysis and de novo lipogenesis in BAT.
However, one-year old ms-DKO mice surprisingly showed elevated γcyto-actin expression in skeletal muscle extracts compared to wt (3.6±0.8 fold increase, Fig. 1B).
Primary astrocytes from senescence-accelerated mouse (SAM) showed elevated oxidative stress and reduced neuroprotective capacity (Garcia-Matas et al., 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com