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Tat-Smad7 treated mice show accelerated healing compared to the control group.
After birth, homozygous (Lmna−/−) mice show accelerated features of aging and have a shorter life span (∼6 weeks) than their heterozygous counterparts.
(Fig. 5) The C57BL/6 background includes alleles that promote progressive sensorineural hearing loss [28], therefore both wild type and MPS IIIB mice show accelerated high frequency (40 kHz) ABR threshold elevation (Fig. 6).
TIMP-3-deficient mice show accelerated mammary involution and increased rates of adipogenesis [ 94].
Interestingly, LSP1-/ null mice show accelerated healing of skin wounds, along with enhanced collagen synthesis, re-epithelialization, and angiogenesis.
GSK3β knock-out mice show accelerated wound closure and fibrogenesis, thus suggesting an inhibitory role of this kinase [ 34].
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However, the tumor cells isolated from adiponectin haploinsufficient mice showed accelerated proliferation in culture, indicating that these cells are different from those isolated from wild-type mice.
RP105-deficient mice showed accelerated onset of arthritis and increased severity.
Our studies with heterozygote deletion of the elastin gene in mice showed accelerated arteriogenesis (Szymanski et al. unpublished).
Notably, K5-SOS Hdac1Δ/Δep mice showed accelerated onset of tumour development and a significant increase in relative tail tumour weight.
The GMF-TG mice showed accelerated aging in the kidney, compared with wild-type mice, showing increased TGF-β1, CTGF gene and serum creatinine.
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