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Furthermore, AAV serotype 9 (AAV9) is capable of passing through the developing blood-brain and blood-retina barriers in young mice, serving as a vector for GRN in mouse pups to target the retina and brain before degeneration begins.
Syngeneic mice (n = 48) were used in this study, including 24 mice serving as lung transplant donors and 24 mice serving as recipients.
The mice serving as the treated seed mice received anidulafungin at a dose 1 mg/kg, i.p. 3x per week.
Mice arising from germline transmission of the mutated ES genome were backbred 10 generations onto C57BL/6 for the current studies, with wild type C57BL/6 mice serving as controls.
Wild-type mice serving as controls received either PMA or vehicle.
Four-weeks-old C57B6 female mice serving as normal controls were killed, and the fourth inguinal MGs were dissected.
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Mice exposed to nebulized water and sentinel mice served as controls.
Sham-operated mice served as controls.
Amplicons from WT mice served as negative controls (c).
Plasma from four WT mice served as controls.
Normally ambulating mice served as controls (n = 30).
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