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Although not a good animal model for AD, the PS1 mice serves as a good example of the neuropathological consequences of intraneuronal Aβ.
F. novicida infection in mice serves as a model for human infection with the category A pathogen, F.tularensis ssp tularensis [36].
The endogenous viral superantigen 7 in DBA/2 mice serves as a target antigen on syngeneic ESb-MP lymphoma cells for allogeneic graft- vs-leukaemia reactive cells.
Radiation-induced acute myeloid leukaemia (AML) in some strains of mice serves as a well-established animal model to explore this issue.
The ability of AChE inhibitors, known to improve cognition in PDD, in reversing visual-spatial memory deficits in DA-depleted CHTHET mice serves as further confirmation of essential similarities between the neuropathology in the DA-depleted CHTHET mouse and PDD.
To our knowledge, the system using NOG mice serves as a reliable experimental model in which human-derived cancer cell lines transplanted in vivo generate metastases forming solid tumors in organs including the liver in vivo with greater reproducibility than the conventional model using NOD mice which lack T-cells and B-cells but not NK cells [ 17].
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Mice exposed to nebulized water and sentinel mice served as controls.
Mice are not obviously people's equal in terms of intellect, but scientists have found ingenious ways to make mice serve as models for psychiatric diseases.
Normally ambulating mice served as controls (n = 30).
T and C mice served as intermediate reference groups.
Syngeneic mice (n = 48) were used in this study, including 24 mice serving as lung transplant donors and 24 mice serving as recipients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com