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Exact(9)
Even in HLA-DR3.IFN-γ−/− mice, serum levels of several cytokines/chemokines were elevated following SEB challenge.
However, in Ki26894-treated mice, serum levels of soluble IL-6 receptor remained low (Figure 7A) and only marginal bone destruction was observed on X-ray radiography (Figure 7B).
The most pronounced changes in serum cytokine and chemokine levels are shown in figure 5. Compared to sera from unchallenged control mice, serum levels of IFNγ (mean 7 21-fold 7 21-fold, increase–40-fold increase), and IL-67 (mean 8–12—fold increase) levels were significandly raised in immeanzed, but not un-immunized mice on day 2 of infection.
In young female mice, serum levels of estradiol varied considerably in a manner consistent with reproductive cycling (62 ± 123 pg/ml, n = 23).
In mdx mice, serum levels of these miRNA are lowered in animals following exon skipping inducing treatment [ 36, 43], suggesting that their levels correlate with disease severity.
Consistent with our observations in aged CreLysM Casp8fl/fl mice, serum levels of sRANKL were elevated in WT + CreLysM Casp8fl/fl mice compared with WT + Casp8fl/fl mice (Fig. 3j).
Similar(51)
Paraoxonase (PON) 1 arylesterase activity, was higher in Spalax compared to both human and mouse serum levels.
We have previously found that mouse serum levels of specific subtypes of 5′ tRNA halves change markedly with age, and these changes can be attenuated by CR (Dhahbi et al., 2013b).
Mouse serum levels were determined by sandwich ELISA, as per the manufacturer's protocol (R&D Systems #DY1679), with the recommended pretreatment of sample with acid/urea, followed by neutralization.
In WT mice, serum progesterone levels were considerably increased during early pregnancy, whereas the level remained unchanged in a subpopulation of Neat1 KO mice (Fig. 1L).
Compared with the WT mice, the serum levels of TNFα and IL-1β were higher in the Appl2 KO mice.
Related(16)
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