This number was further increased by transplantation of NPCs derived from IL-1raTG mice, rising to a level significantly greater than in all other groups (including the WT NPCs-transplanted group).
We previously showed that, in prion-diseased mice, rising levels of misfolded prion protein (PrP) promote sustained elevation of eIF2 α-P in neurons, leading to the protracted, uncompensated decline in global translation rates, resulting in the loss of crucial proteins that contributes to synaptic failure and neuronal death.
As shown in Fig. 1A, the blood glucose level of control mice remained at ~8 mmol/l throughout the study course, whereas the blood glucose level of STZ-treated mice rose to ~24 mmol/l over the course of 2 weeks and stayed elevated in the range of 22 28 mmol/l (averaged ~threefold above the control) for the remaining 6 weeks of the study.
In our studies, M. bovis BCG counts in the spleens and livers of infected mice rose to a maximum after 2 weeks, and subsequently declined to nearly undetectable levels with the induction of adaptive immunity.
Changes in p53 function may also explain in part why tumor incidence in wildtype mice rises dramatically with age.
As expected, under conditions of increased caloric intake, core body temperature in Eps8KO mice rose to levels of WT mice (Fig. 4F), while it remained unvaried in mice fed a normal diet.
Blood ALT levels in YapKIAlb-Cre and WT mice rose to similar levels, indicating comparable hepatocyte damage.
In studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol.
Consistent with previous studies (36, 37) serum CK was elevated in newborn mice, but then became undetectable during the 1st and 2nd week of age (except for 1 mouse), rising again at 3 and 12 weeks followed by a stabilization (Fig. 5C).
The mouse rises and goes over to the cupboard, which is empty except for a tin box with the word "Cheese" on it.
