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However, characterization of Lmod3 PB/PB mice revealed specific atrophy of fast fibers.
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In studies with 68Ga-labeled Siglec-9 peptide and blocking and a comparison of VAP-1 positive WT mice and VAP-1 negative KO mice revealed 60%and50%0% specific binding of the peptide in the livers of each genotype of mouse, respectively [41].
Recent studies with gene deficient mice revealed more specific functions of MMPs, e.g. the cleavage of chemokines, thereby stimulating inflammatory responses (Dufour & Overall, 2013).
The analysis of both parkin expression and activity in two affected tissues of MSD mice revealed tissue-specific defects in MSD mice.
Other metabolic challenges to fat-DN mice may reveal specific functions for Acvr2b ligands in adipocytes.
Mouse visual function was determined using visual evoked potentials, which revealed specific visual impairment in contrast sensitivity.
Immunohistochemistry revealed specific Morg1 expression in reactive astrocytes in the ipsilateral (ischemic) hemisphere in Morg1+/− and WT mice, especially in the penumbral regions.
However, a more thorough analysis of motor behavior in En2−/− mice revealed deficits in specific motor tasks.
Detailed analysis of the trabecular bone parameters in the 13-week old female mice revealed interesting site-specific responses to Lef1 haploinsufficiency.
Lack of GC-C expression in outbred mice versus inbred C57BL6/J mice revealed a strain-specific protective role for GC-C in the liver following acute CCl4 injury.
However, extensive pharmacokinetic analysis in SPARC+/+ and SPARC−/− mice revealed a SPARC-specific distribution pattern of low-dose m-nab-paclitaxel that was independent from paclitaxel metabolism and saturable at higher concentrations of nab-paclitaxel in tumour-bearing mice.
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