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A more detailed comparative analysis of KPL-4 cells taken from cell culture and circulating KPL-4 cells in blood from tumour-bearing mice revealed changes in expression of EMT-associated genes with upregulation of Twist, Collagen-alpha-2 V -chain (Collagen-alpha-2 V -chain Collagen-alpha-2 V -chainoesin (MSN) and beta-type platelet-derived growth faCollagen-alpha-2 V -chain the latter.
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Gene expression profiling of the Cln1/5 dko mouse cortex revealed changes in genes involved particularly in immune response, nerve ensheathment and transmission of nerve impulse.
Microarray experiments examining global changes in splicing in SMA mice have not revealed changes in alternative splicing of any known regulators of splicing (14, 16).
Hematological analysis of blood from Vav1-P1cKO mice revealed significant changes in RBC physiology without significant anemia (Table 1).
Conversely, the phenotypic analysis of Ms5Yah mice revealed dramatic changes in viability, morphology, motor coordination and cognition.
Our analysis of the metabolomic profile of the plasma of old SAMP8 mice revealed profound changes in several biological pathways in comparison to the young SAMP mice.
Analyses of LPCAT3-deficient mice revealed complex changes in the lipidome, but among the major fatty acids, the most commonly decreased one was arachidonate.
The EMG analysis of V1 IN-ablated mice revealed marked changes in the duration and co-activity of TA and GS muscle activity.
Immunohistochemical staining for synaptic markers in 4 (pre/early-symptomatic) and 10 (late-symptomatic -month-old Clate-symptomatic -month-oldlar late-symptomatic -month-oldn Ppt1 deficient mice.
Proteomic analysis of the hippocampus of SMA mice revealed numerous changes in the expression of proteins involved in the regulation of cell proliferation, growth, migration and development (Wishart et al., 2010).
Quantification of Gfap mRNA levels in the same mice revealed fold changes similar to those found for promoter activity in olfactory bulb, hippocampus, cerebral cortex and cerebellum, and more modest increases in brain stem and spinal cord.
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