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Fourteen months old tg-ArcSwe mice required a longer time to re-habituate to the IntelliCages than non-tg mice.
On the other hand, the measurement of blood glucose level during OGTT showed that IRE1α CKO mice have a significantly higher blood glucose level at its peak than control mice and that IRE1α CKO mice required a longer time for blood glucose level to recover than control mice (Figure 1B).
Nude mice required a rather higher dose of the priming agent, Propionibacterium acnes, than heterozygote littermates.
This suggests that Myk/+ mice required a longer initial exposure time to recognize the pre-exposed juvenile.
The protection is dose dependent, and Balb/c mice required a higher dose IFN-α than did Sv129 mice to be protected.
We also noticed that the rescue of dKO mice required a minimal dose of 5E + 12 vg of scAAV9-U7ex23 injected, suggesting a threshold of dystrophin restoration necessary for the dKO survival.
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The lack of T cell phenotype in these mice requires a re-assessment of the proposed role of ADAM17 in the thymus.
Vitamin D is a critical regulator of calcium homeostasis, and VDR KO mice require a high calcium "rescue" diet during early development to prevent skeletal defects and maintain fertility [16], [25].
Accurate diagnosis of lesions in genetically engineered mice requires a level of experience and expertise that is not available in all institutions.
Commonly used serologic tests for deer mice require a minimum of 3 5 hours to complete (2, 5, 6 ) and thus are impractical to use in the field in a single day without putting the rodents at risk for death from heat, cold, dehydration, trap injuries, and other hazards while tests are being conducted.
When the Arap1-/ mice were treated with an ACE inhibitor, the systolic blood pressure decreased to a larger extent than in the wildtype mice, suggesting again that blood pressure maintenance in the Arap1-/ mice requires an activated RAS.
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