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Injecting these cells into the mice represents an isogenic relationship between the host and the tumor cells, and allows the studies of molecularly modified tumor cells.
The achievement of Vp16-Jazz and Vp16-Jazz/mdx mice represents an useful animal model for use in drug discovery and therapeutics.
We suggest that liver-specific deletion of the Notch2 gene in Notch2-cko mice represents an improved and more specific model than Jag1dDSL/+ Notch2del1/+ mice for studying the role of Notch signaling during bile duct morphogenesis and remodeling.
The increase in total IgE and IgG1 in the HDE-challenged mice represents an increase in polyclonal, antigen non-specific IgE.
Given that RAS inhibitors are cardioprotective in diabetes, the development of cardiac dysfunction in diabetic AT1a-KO mice represents an important finding.
The causes of this malformation remain unknown, although the discovery that it can have a genetic basis in mice represents an important step towards the understanding of its pathogenesis.
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The appearance of these mice represents a sort of laboratory-created evolutionary balancing act, following by several years the creation of enhanced cats.
Working with mice represents a smart method to study pathophysiological mechanisms in vivo.
Thus this stress/freezing curve in control mice represents a non-typical inverted-U shaped curve for both conditionings.
We hypothesized that transplantation of NA-BMCs and bone marrow of C57Bl/6 wild-type mice represents a syngeneic transplantation setting in contrast to bone marrow or NA-BMCs derived from wild type Balb/c representing an allogeneic transplantation setting.
In summary, the identification of a QTL on chromosome X regulating the timing of VO in mice represents a step further towards finding of novel factors regulating the onset of puberty.
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