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Experiments on mice, reported in the journal Cell, suggested hair stem cells were controlled by fat.
The Hdac6 tg mice reported in this study provide the proof of principle of anti-virus function by Hdac6 in vivo.
Total Abeta40 in vehicle control, both male and female (Fig. 4A grey columns), showed levels consistent with the expected age-dependent increase of Abeta in naïve mice reported in Hirata-Fukae et al. (2008) (Fig. 4A dotted lines).
In contrast to the knock-in mice reported in this study, αB−/− knockout mice develop degeneration of certain skeletal muscles, most notably axial muscles and the tongue with relative sparing of the limb muscle, at about 65 weeks of age [8].
The time-course and spatial extent of the circuitry traced out using MEMRI in the WT littermates of DAT KO mice was substantially different than that observed for the WT littermates of SERT KO mice reported in our previous study, although the reasons for these differences are not clear [33].
Given the fact, that the phenotype of Col1a1-Krm2 mise is apparently more severe than the phenotype of Col1a1-Dkk1 transgenic mice reported in the literature [26], it was also important to compare the genome-wide expression analysis of wildtype and Col1a1-Krm2 transgenic osteoblasts to another Gene Chip hybridization experiment, where we have treated wildtype osteoblasts with Dkk1 for 6 hours.
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Two recent studies in mice reported sex differences in gene expression networks of correlated transcripts [ 17, 18].
It was more difficult to explain the complete prevention of diabetes observed in MyD88−/−NOD mice reported by Chervonsky and observed in our study [36].
Most studies performed in mice report robust in vivo suppressive activity of TGF-β-induced Tregs in the treatment of colitis [22] and EAE [41].
Plxnd1+/o and Sema3E+/o mice were reported in ref. 29.
The biochemical characteristics of wild type and ob/ob mice are reported in Table S1.
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