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The blood pharmacokinetics of the panitumumab F ab' 2 in tumor-bearing mice reported here is consistent with that of other F ab' 2 fragments described in the literature [13].
The SRT monotherapy studies in Fabry mice reported here provide evidence that therapeutic benefit might be attained through this approach.
Our observation of coloboma in LMO4 germline deleted mice, reported here for the first time, lead us to explore the function of LMO4 in retinal development.
However, like the MKO mice reported here, mice with a targeted destruction of mRGCs retain a behavioural aversion to light [18], indicating that mRGCs are probably not an absolute requirement for BLA.
Thus, the PTPN4-deficient mice reported here are on a mixed 129 SvEv×C57backgroundround whereas the PTPN4-deficient mice that were reported to exhibit motor learning defects are on a 129SvJ background [33].
The pattern of α-DG expression in developing T cells in the thymus of adult mice reported here varies from the results of a recent study on the dynamics of α-DG expression in T cells from fetal thymus [27].
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But mice treated with the RNAi virus showed signs of improvement; they kept their balance on a rotating rod longer than untreated diseased mice (but not as long as healthy mice), Davidson reported here on 4 and 5 June at a meeting of the American Society of Gene Therapy.
The Sulf1; Sulf2-deficient mice, as reported here, showed phenotypic similarity to the Hs2st-deficient mice, albeit of lesser severity.
Even so, the results of the studies of mice USVs reported here support the view expressed by the Scattoni et al. (2008a) study that communicative behavior in mice, particularly their vocalizations, constitutes a useful assay for studying impairment of social behavior, including autism.
ST. LOUIS, MISSOURI--A new kind of gene therapy can cure the metabolic disorder phenylketonuria in mice, researchers reported here this week at the annual meeting of the American Society of Gene Therapy.
Reduced net hippocampal neurogenesis in GR+/ − mice as reported here fits well with these reports.
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