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Following treatment with DEDTC or selenium an increase in the number of both dead and apoptotic cells were seen in the controls within the first 24 hours after TBI while the degree of damage in the ZnT3-KO mice remained largely unchanged.
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As human CD47 does not cross react with murine SIRPα and macrophages in most immunodeficient mice remain largely intact [ 20], we reasoned that lack of engagement of CD47- SIRPα might be a contributing factor for the low metastatic potential of many xenografted tumors.
Embryonic lethal phenotypes that are similar to what has been known for a long time in mice have remained largely unknown because of the difficulty in arriving at a molecular diagnosis.
In contrast, Nlrp1, Asc, Rigi, Nod1 and Nod2 remained largely unaltered from WT mice.
Systemic inflammatory cytokine levels remained largely unchanged in ob/ob and db/db mice.
In contrast, the expression level of Irs1, which is not a FOXO1 target gene, remained largely unchanged between LMKO and control mice disregarding the feeding status.
The middle and basal cochlear turns of kanamycin-treated mice showed complete loss of outer hair cells, while the inner hair cells remained largely intact.
Thus, the findings in man and mice collectively underline the importance of TRα1 signalling for proper brain development–unfortunately, the underlying molecular mechanisms have remained largely enigmatic.
Johnson, however, remained largely noncommittal.
After that, Bayda remained largely quiet.
(Tobacco exports remained largely tax-exempt).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com