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Our results revealed that E. purpurea, but not thyroxin, had the capacity to increase NK cell numbers, in aging mice, reflecting increased new NK cell production in their bone marrow generation site, leading to an increase in the absolute numbers of NK cells in the spleen, their primary destiny.
Consequently, the Bax/Bcl-2 ratio was higher in tibias of transgenic mice compared to wild type mice, reflecting increased apoptosis (Figure 6F).
In this study, exposure to hCG 16 h prior to cull resulted in a significant increase in testis weight in adult control mice, reflecting increased IF volume, but not in SMARKO adults (Figure 8A).
Gomori Trichrome staining showed that collagen fibers were more closely packed in angiotensin II-treated mice compared with control mice, reflecting increased collagen deposition.
In further IHC experiments with an F4/80 antibody [ 11], macrophage infiltration was abundant in gastric mucosa of Gan mice, reflecting increased prostaglandin E2 expression [ 11].
As reported previously (14), adrenal glands were heavier (P=0.001) in DKO (0.20±0.01 mg/g body wt; n=6) than ApoE-KO (0.14±0.01 mg/g body weight; n=7) mice, reflecting increased adrenal corticosterone production with 11β-reductase deficiency.
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Whether the increased expression of FasL in the retina of TNFα treated mice reflects increased migration of FasL+ microglial cells to the retina and/or increased level of FasL expression/cell remains to be determined.
While peak frequencies were reached in young mice by day 14 after the boost, numbers peaked later in young but not aged mice reflecting increases of circulating CD8+ T cells in the former.
PLP-hαSYN transgenic mice showed significantly increased LC3B II/actin ratios in the brain as compared to wild-type age-matched mice possibly reflecting increased level of autophagy due to transgenic hαSYN overexpression; however, PSI treatment had no further effect on this ratio either in transgenic or in wild-type mice (Fig. 4d).
An elevation in RQ was observed in knockout mice during the late day, possibly reflecting increased daytime food intake.
Leptin increases in adult AC3−/− mice may reflect increased adipocyte size and obesity.
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