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As shown in Fig. 3a c, we observed a statistically significant decrease in the percentage of Evan's blue dye (EBD) positive fibers in Sgca null:Nfix null mice if compared to dystrophic Sgca null mice, reflecting a higher sarcolemmal integrity in mice lacking Nfix.
In females, the force-frequency curve for aged mice is shifted leftwards compared with the curve for adult mice, reflecting a lower half-frequency in aged mice (49.7±0.9 Hz for aged, 53.6±1.4 Hz for adult, P = 0.0350).
As can be seen in Fig. 3A, pig insulin blood levels were markedly enhanced in Factor VIII KO SCID mice compared to Factor VIII positive SCID mice, reflecting a growth advantage in the Factor VIII KO recipients.
Interestingly, serum AST activity in hepatectomized animals, a marker of liver injury, was about a third of the WT value in the double KO mice, reflecting a decrease in liver injury after PH (Fig. 1F).
In males, the force-frequency curve for aged mice is shifted upwards at low frequencies compared with the curve for adult mice, reflecting a higher twitch-to-tetanus ratio in aged mice (22.5±0.7% for aged, 19.3±0.4% for adult, P<0.0001).
Our data suggest differential effects of diet on hepatic lipid metabolism namely downregulation of cholesterol biosynthesis in herring-fed mice and an enrichment of chylomicrons in livers from the beef-fed mice, reflecting a disturbed clearance of circulating lipoprotein particles in mice fed a beef-based diet.
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Kuswanto, W. et al. Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells.
The results thus indicate that, for the lupus-specific autoantibodies, the absence of antibody in autoimmune mice reflects a deficit in precursor B lymphocytes rather than an active regulatory mechanism.
Therefore, we considered that results obtained using iv/iv mice reflect a consequence of hippocampal abnormality.
Autoimmune insulitis in NOD mice reflects a condition of disturbed immune homeostasis that involves deregulation of both effector (Teff) and regulatory T cells (Treg).
These findings support the notion that enhanced FAA in KO mice reflects a behavioral manifestation of a food-driven circadian oscillator and suggest that 5-HT2CRs gate food-anticipatory activity through mechanisms involving extrahypothalamic neural pathways.
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