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Taken together, the dysfunctional neurotransmission and impaired synaptic plasticity seen in the A53T-SNCA overexpressing mice reflect early changes within the basal ganglia prior to frank neurodegeneration.
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The sequence of early, nonlinear changes of cell densities in VZ/SVZ, IZ and PP/SP of ablated mice reflected early compensatory changes of the proliferative matrix, which resulted from the generation, then replacement, of killed GPT cells.
This may reflect early neuronal damage [ 30].
Therefore, the vessel changes appear to reflect early changes.
These two factors reflect early loosening after TKA.
In both, the findings do not reflect early disease.
These symptoms may reflect early gray matter cortical involvement.
3 Negative values reflect early arrivals and positive values reflect tardy arrivals.
We first evaluated the antifibrotic properties of the monoclonal anti-IL-6R antibody, MR16-1, in the bleomycin-induced dermal fibrosis mouse model, reflecting early and inflammatory stages of SSc.
The in vitro experiments were performed with human and rat bone marrow-derived stromal cells (BMSC) reflecting osteoblast-precursor cells, with human MG-63 cell line, primary rat calvaria osteoblasts (rCaOB) and mouse MC3T3-E1 celineine reflecting early premature osteoblasts, and with human SaOS-2 cell line and mouse MLO-Y4 cell line reflecting late mature osteoblasts, respectively.
Viral doses were chosen to reflect earlier studies [ 2, 18].
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