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The weights of injected mice reduced initially by 5 10%, then recovered after 1 week.
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Compared with control mice, MGsKO mice had reduced muscle mass with decreased cross-sectional area and force production.
Platelet-depleted B6 mice transfused with platelets from PF4-/ mice displayed reduced tissue damage compared with controls.
FADD-D mice exhibit reduced body size.
Heterozygous Mpdz +/- mice displayed reduced opioid tolerance and OIH.
IL-6 deficient mice exhibit reduced expression of AVP [187].
In Tex14 knockout mice, initially markedly reduced numbers of late meiotic and post meiotic cells are detected and in older animals more severe phenotype with decrease in all germ cell numbers is present [ 15].
Moreover, in Prkg1SMr mice rebound sleep was apparent already after 2 h whereas in control mice, sleep time was initially reduced and only after 6 h did accumulated values exceed baseline (Fig. 2C).
CD103-deficient mice were initially shown to have reduced numbers of intestinal intraepithelial lymphocytes and lamina propria (LP) T cells, suggesting a role for this integrin in the localization of T cells within intestinal tissue [7].
DC-specific conditional p28-deficient mice were initially demonstrated to have reduced resistance to progression of tumors such as MCA-induced fibrosarcoma and transplanted melanoma B16.
H1R−/−/H2R−/− mice apparently behaved similar to HDC knockout mice in reducing sepsis-related pathological changes.
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