Exact(6)
Arthritis was significantly attenuated in C57BL/6 mice recipient of cells from RORγt Tg mice.
Interestingly, arthritis was significantly suppressed in mice recipient of cells from RORγt Tg mice but not those from C57BL/6 mice.
To generate mixed bone marrow chimeric mice, recipient Rag1 -/- mice were sublethally irradiated and reconstituted i.v. with 2 x 10 bone marrow hematopoietic stem cells.
Arthritis was also suppressed in mice recipient of CD4+ cells isolated from RORγt Tg mice only, but not from C57BL/6 mice.
For transplantation experiments in mdx mice, recipient animals were anaesthetized via isoflurane inhalation and received intramuscular injections into the tibialis anterior of 10 µL NTX (10-5M) for local tissue injury.
For transplantation experiments in Nod/SCID mice, recipient animals were anaesthetized via isoflurane inhalation and received 10 µl intramuscular injections into the tibialis anterior of either 10 µg/ml notexin for local tissue injury, or freshly isolated muscle stem cells (MuSC) and FAPs cells resuspended in PBS.
Similar(54)
Older non-obese diabetic (NOD) mice recipients (3m, at disease-onset stage) receiving syngeneic BM-HSC progressed more rapidly to end-stage diabetes post-transplantation than younger recipients (4-6w, at disease-initiation stage).
As shown in Figure 6, the MPO activity in the grafted kidneys of nu/nu mice recipients was very low (0.9±0.6 mU/ml).
In all, 2 × 10 hepatocytes were injected immediately into the spleens of mice recipients.
Here, we confirmed that transgenic hepatocytes with sustained FoxM1 expression have enhanced capacity for liver repopulation in the Fah−/− mice recipients with induced host hepatocyte death and also in the Fah−/− mice recipients with normal healthy hepatocytes after partial hepatectomy.
No tumor was found in all tissues of the mice recipients, and the livers of recipients kept in the normal morphological structure and size with healthy sinusoidal plates.
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