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For example, mice receiving recombinant leptin enhanced fibrogenic response, while leptin receptor-deficient fa/fa rat and db/db mice are resistant to the development of liver fibrosis [5], [6].
LPS-sensitive C3H/HeOuJ mice receiving recombinant pSM539 bacteria intra-peritoneally 24 hours before administration of a lethal dose of bacterial LPS could survive significantly longer than mice administered the control pSM214 bacteria or PBS, in agreement with previous data on the efficacy of IL-1Ra in inhibiting LPS-induced shock [ 13- 15].
Mice receiving recombinant human α-galactosidase A (1 mg/kg) were dosed by tail-vein injection.
Mice receiving recombinant adenovirus expressing human Rspo1 (a potent Wnt signal enhancer and one of the four analogs of R-spondin) before potentially lethal TBI or local abdominal irradiation had higher survival than the control group.
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In brief, New Zealand White rabbits and Balb/c mice received recombinant protein in TiterMax Gold Adjuvant (Sigma) intradermally for first immunization and subcutaneously for three boosts.
Some mice received recombinant murine soluble FasL alone (R & D Systems) (100 ng/0.5 µl sterile physiological saline) or in combination with the TNFα (100 ng sFasL/1 ng TNFα/0.5 µl sterile physiological saline).
In particular, we previously reported a significant suppression of the systemic cell-mediated response toward wheat gliadin in DQ8 transgenic mice receiving nasally a recombinant α-gliadin.
Recently, Smad7, an intracellular antagonist of TGFβ signaling, has been shown to attenuate bleomycin-induced lung fibrosis in mice receiving intratracheal injection of recombinant adenovirus overexpressing Smad7 [ 42].
Female mice receiving a chronic infusion of recombinant PRL had higher left ventricular myocardial vasoinhibin levels than controls (54).
We observed that tumor growth was significantly inhibited in mice receiving DT385 by day 19 (23%) when compared to control mice treated with an identical concentration of the recombinant control protein, SUMO (Figure 7).
Mice primed and boosted with a low dose of recombinant sHA.GCN4pII without an adjuvant had an improved humoral response to the H3N2 HA compared to mice receiving the unmodified sHA protein.
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