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Mice treated with PPMO before and after VEEV infection were completely protected from lethal outcome while mice receiving only post-infection PPMO treatment were partially protected.
However, the transient decline evident at day 9 even in the present group of mice receiving only 10 MBq [177Lu]-DOTATATE suggests the occurrence of acute toxicity at an activity far below that required to provoke chronic renal failure, which takes several months to develop.
The mice receiving only huMSC did not develop any tumors (Figure 4A).
In CTGF-TG mice, the contractile performance after Ang II was preserved to the level of mice receiving only a sham infusion.
Immunohistological analysis of recipient mice receiving only PBS revealed only scattered human T cells but these cells were readily identified by FACS analysis of collagenase digested spleens.
During a combination treatment trial using two such compounds, N-butyldeoxynojirimycin (NB-DNJ) and allopregnanolone, we noted increased lifespan for Npc1−/− mice receiving only 2-hydroxypropyl-β-cyclodextrin (CD), the vehicle for allopregnanolone.
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Six other mice received only olive oil and died within three days.
Control mice received only water.
Control mice received only saline infusion.
A group of control mice received only saline.
The mice received 20 mg/kg compounds BMH-15 and -22 three times a week, while control mice received only DMSO.
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