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The substitution of Gly with Ala significantly enhanced the melanoma uptake of 99mTc-RAD-Lys(Arg11 CCMSH compared to 99mTc-RGD-Lys(Arg11 CCMSH in B16/F1 melanoma-bearing C57 mice, providing a new insight into the design of α-MSH peptides for melanoma targeting.
They also had lower levels of PER2, a protein involved in circadian rhythms, than unmutated mice, providing a possible molecular explanation for the unusual sleep patterns in the family.
In 2017, a group of scientists used the Bio-X printer to create a gel containing human cartilage cells and implanted them in mice, providing a proof of concept for a future where knee and other joint replacements might be made out of living tissue rather than metal or plastic.
Furthermore, we show for the first time that DA turnover is increased in Pink1−/− mice, providing a potential mechanism for the decline in DA in the absence of (significant) neuronal loss.
Interestingly, the lack of LMP2 ameliorated the hypothyroidism seen in thyr-IFNγ transgenic mice, providing a novel explanation for the pathogenesis of hypothyroidism typically found in patients with autoimmune thyroiditis.
Moreover, recently we have reported salivary dysfunction in IL-12 transgenic mice, providing a new model of SS [ 31].
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The bacillus can grow in the footpads of mice, providing an important mechanism for bacillus cultivation for experimental study.
These mice provide a useful model to study neurofibromin deficiency in hematopoiesis.
Such humanized mice provide a new opportunity to perform pre-clinical studies of intractable human pathogens.
Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways.
As some of these authors have previously shown3, the persevering mice provide a model for persistent drug use despite negative consequences, and parallel the subset of human drug users whose drug use becomes compulsive.
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