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Mice provided by the Beijing Vital River Experimental Animals Centre (Beijing, People's Republic of China) were housed under conditions of 12 hr light and 12 hr dark in a temperature- (23 ± 1°C) and humidity- (60 ± 5%) controlled room.
parkin +/+ or parkin −/− mice (provided by Prof. Zhuohua Zhang from Central South University) were subjected to a mice hypoxic chamber for the indicated duration, with an atmosphere of 8% O2 in nitrogen and free access to food and water.
FVB/NJ mice (Jackson Laboratory stock number 001800), Math1-CreER™ mice (provided by Dr. S.J. Baker, St .Jude, Memphis, TN), and HprtCre mice (provided by Dr. M. Krasnow, Stanford University) were used.
Live S. Mansoni eggs were purified from the livers from mice heavily infected with S. Mansoni, (mice provided by Dr. Fred Lewis (Biomedical Research Laboratory, Rockville, MD)).
Homozygous DMP1-GFP transgenic mice (provided by D. W. Rowe) [49] were crossed with hemizygous DMP1-caPTHR1 mice to generate DMP1-GFP-positive offspring with and without the DMP1-caPTHR1 transgene.
DUC18 TCR transgenic mice [30] are on a BALB/c background and were bred to Thy1.1 BALB/c mice (provided by Dr. Hyam Levitsky, Johns Hopkins) to generate Thy1.1+ DUC18 mice.
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Specific pathogen-free Foxp3-GFP-DTR (C57BL/6) mice were provided by A. Rudensky (Washington University/Sloan-Kettering Institute).
Oct4-GFP mice were kindly provided by A. Surani.
TCCR KO mice were provided by Dr. Fred de Sauvage (Genentech), while other mice were purchased from commercial sources.
The tau-lacZ knock-in mice were raised in our laboratory from mice generously provided by Dr. Samer Hattar (Johns Hopkins University).
PD-1−/− mice (kindly provided by Prof Tasuku Honjo, Kyoto University) were crossed with Tg4 (CD90.1) mice to obtain Tg4.PD-1−/− (CD90.1) mice.
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