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Because of the relative similarity between the mouse and human genome, knockout mice provided a valuable framework for the development of treatments and therapies for the diseases and disorders that they modeled.
There, while working on the genetics of pox viruses and the immune system, he discovered that mousepox, a disease in mice, provided a useful model for investigating the incubation period of infectious diseases like smallpox, measles and chickenpox.
ApoE knockout (ApoE−/−) mice provided a high fat western diet develop morbid obesity and have evidence of chronic inflammation.
Phosphate wasting seen in the NHERF-1 null mice provided a new experimental system for defining the role of PDZ adapters in the hormonal control of ion transport and renal disease.
With respect to this population, the procedure identified a total of 454 signature transcripts, and nearly all of these were elevated in mice provided a HF diet relative to mice provided a control diet (Figure 4).
Subcutaneous injection of rapidly growing human cancer cells into nude mice provided a setting in which tumor growth could be assessed in a relatively short time span.
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Rab8a-deficient mice provided an opportunity to examine the crypt response to weakened Wnt production at the stem cell niche.
Studies in irradiated embryonic fibroblast from telomerase-deficient Terc −/− mice provided an important clue to understand the basis of the increased sensitivity of this mouse model.
These mice provide a useful model to study neurofibromin deficiency in hematopoiesis.
Such humanized mice provide a new opportunity to perform pre-clinical studies of intractable human pathogens.
Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways.
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