Because of the relative similarity between the mouse and human genome, knockout mice provided a valuable framework for the development of treatments and therapies for the diseases and disorders that they modeled.
There, while working on the genetics of pox viruses and the immune system, he discovered that mousepox, a disease in mice, provided a useful model for investigating the incubation period of infectious diseases like smallpox, measles and chickenpox.
ApoE knockout (ApoE−/−) mice provided a high fat western diet develop morbid obesity and have evidence of chronic inflammation.
Until recently, transgenic mice provided the only experimental model capable of supporting the entire spectrum of LCR activities.
Furthermore, these strains were attenuated in mouse experiments producing no pathological changes and inoculation with these DDDHA strains in mice provided strong protection against lethal wild type infection.
parkin +/+ or parkin −/− mice (provided by Prof. Zhuohua Zhang from Central South University) were subjected to a mice hypoxic chamber for the indicated duration, with an atmosphere of 8% O2 in nitrogen and free access to food and water.
In vivo micro-computed tomography (micro-CT) will offer unique information on the time-related changes in bone mass and structure of living mice, provided that radiation-induced side effects are prevented.
5 naïve mice provided blood as reference ('baseline'baseline
Sham-loaded (n = 9) and normal age-matched control (n = 18) mice provided additional comparisons.
Subsequent mating between adbn+/− and adbn−/− mice provided adbn−/− and littermate control adbn+/− animals.
FVB/NJ mice (Jackson Laboratory stock number 001800), Math1-CreER™ mice (provided by Dr. S.J. Baker, St .Jude, Memphis, TN), and HprtCre mice (provided by Dr. M. Krasnow, Stanford University) were used.
