As an intermediate approach that combines the practical advantages of cell line based approaches with the cellular specificity of transgenic studies, we adapted the electroporation of mouse retinal explants to provide rapid and reproducible quantitation of cell-specific promoter activity.
They also provide rapid and accurate responses to controls.
These models are easy to implement and provide rapid simulations.
We therefore anticipate that these reagents will provide rapid activation, however, they are likely to suffer from rapid clearance.
PTMs provide rapid and reversible mechanisms for regulating protein activity.
Systemic corticosteroids are used to provide rapid relief of symptoms.
Thus, SR-BI/apoE dKO mice provide a very rapid, small animal model that mimics many cardinal features of human coronary heart disease [2], [11], [29].
This label-free method is 100 times more sensitive than the mouse assay, potentially providing rapid read-out of small amounts of toxin for environmental surveillance and the quality control of pharmaceutical preparations.
In this study, we validated a standardised and mainly automated quantitative assessment of histopathological parameters in the mdx mouse model that provides rapid and unbiased results.
These results suggest that our system provides rapid and efficient cloning of functional antigen-specific human and mouse TCRs and contributes to TCR-based immunotherapy for cancers and infectious diseases.
