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The present findings in rats do not lend support to proposed somnogenic effects of AMN082, while comparable responses in WT and mGluR7 mice provide further evidence of an off-target action of AMN082 that contributes to its waking properties.
Real-time RT-PCR experiments measuring Axin2 transcript levels in the GFP+ cells of Eomes::GFP mice provide further evidence that β-catenin signaling is reduced in intermediate progenitors.
Studies of ACTN3 knockout mice provide further insights [ 58].
Our findings in UCN3OE mice provide further evidence for this link between anxiety, hyporesponsiveness of the HPA axis, and associated dysregulation of serotonergic function, specifically attenuated 5-HT1AR responsiveness.
The deficits in sociability and social recognition in both Nrxn1α HET and Nrxn2α HET mice provide further evidence for the role of these genes in the genesis of behaviors relating to autism and schizophrenia.
These findings on the transmission of H-type into transgenic mice provide further evidence for the distinct biologic properties of this cattle TSE compared to L-type BSE and typical BSE.
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This was true for both WT and KR mice, providing further evidence that the maturation of class II MHC molecules is normal in the I-Aβ-K225R-EGFP mice.
The recent report showing isolation and culture of germline stem cells from adult mouse ovaries [5], which restored fertility after injection into infertile mice, provides further evidence to support the presence of germ line stem cells in mammalian ovaries.
Using a model of human trophoblast very early in gestation we show a lack of imprinting of two telomeric genes in the KCNQ1 region and of DCN, whose imprinted expression is placental specific in mice, providing further evidence to suggest that humans do not exhibit placental specific imprinting.
Restored visual acuity in the treated Cngb3−/− mice provided further evidence of rescued cone-mediated visual function.
Studies with Rage-deficient mice provided further in vivo evidence for the central role of RAGE in initiation and perpetuation of immune responses [ 18].
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Justyna Jupowicz-Kozak
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