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Studies of mice provide early evidence that the gut microbiota has an essential role in energy harvest, in that germ-free mice need to consume approximately 30% more calories to sustain a body weight similar to conventionally raised mice [ 52].
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Long-term direct monitoring of host population density and prevalence of hantavirus infection in North American deer mice provided early warning of elevated risk for HPS in the southwestern United States (CDC 1998, 1999; Yates et al. 2002).
If the bactosensor proves safe and effective in humans--whose gut microbiomes are a very different environment than that of mice--it could provide early warning of the presence of tumors or perhaps even circulating metastases.
In mice, immunoglobulin A (IgA) appears to provide early protection against intranasal BCG infection, as IgA-deficient animals succumbed to pulmonary mycobacterial disease as opposed to their wild-type counterparts [ 18].
The Aldh1b1tm1lacZ null mice provide a model whereby early defects in fetal and neonatal stages manifest later in islet functional defects and deterioration of glucose homeostasis, capturing aspects of type 2 diabetes patients.
Tau4RTg2652 mice provide the benefit of an early and consistent cognitive deficit starting at 3 months, as opposed to htau mice which are not distinguished from WT at 4 months.
Thus, Sod1 D83G/D83G mice provide a novel model to test therapeutics aimed at preserving NMJ as well as ameliorating the early stages of motor neuron cell body degeneration.
To get in vivo partial (floxed allele) and/or total excision (null allele) of Lox P-flanked sequence in the targeted loci, heterozygous mice were crossed with EllaCre transgenic mice that provide an early expression of Cre recombinase during embryogenesis.
An internship can provide an early start.
Descriptions of SRC activity, as reported through transgenic mouse models, provide a close correlation with many of the reported effects of early exposure to BPA.
Mouse models provide opportunities to study characteristics of AD in well-controlled environments that can help facilitate development of early interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com