The Oct1 KO mice provide a model to investigate the function of Oct1 systemically.
Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways.
Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients.
Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology.
Taken together, our findings of trastuzumab induced down-regulation of SLC6A6 in human iPSC-derived cardiomyocytes, and the reported phenotypes of dilated cardiomyopathy and altered metabolism in Slc6a6 knock-out mice provide a potential mechanism towards trastuzumab related cardiotoxicity.
HIS mice provide a small animal model to study EBOV isolates, investigate early viral interactions with human immune cells, screen vaccines and therapeutics that modulate the immune system, and investigate sequelae in survivors.
Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion.
Our results support the notion that in vitro cultures derived from Disc1Tm1Kara mice provide a valuable model for future mechanistic analysis of the cellular and biochemical effects of this mutation, and can thus serve as a platform for drug discovery efforts.
These overlaps have led many investigators to conclude that Fmr1 knockout mice provide a unique opportunity to identify interventions that affect autistic-like behaviors [12] [14].
We conclude that CD-1 mice provide a powerful and attractive complementary, readily available and inexpensive resource to currently used mouse populations for genetic studies.
These knockout mice provide a unique platform for future studies to identify the role of CA125/MUC16 in organ homeostasis and ovarian cancer.
