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Transgenic mice produced with the BAC NEUROG3-SeAP/EGFP construct can be used to study neurogenin-3 gene expression and islet cell genesis in intact cells and living mice.
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Consistent with a previous report that APPL1 is dispensable for mouse development (Tan et al., 2010b), crossing APPL1 heterozygous mice produced litters with the expected Mendelian ratios and normal body size.
It has already been mentioned that ACPAs are produced in RA synovial membrane as ELS-containing RA SM transplanted into SCID mice produced ACPAs along with anti-EBV antibodies [41].
Both strains of mice produced amyloid deposits with morphologies that resemble human amyloid.
However, this phenotype was dependent upon the host strain for the transgene as breeding to C57BL/6 or 129Sv mice produced YAC128 mice with normal lifespans (44).
These 5 mice produced a PrPres with lower (≈1.5 kDa) apparent molecular mass of the 3 PrPres glycoforms, which was indistinguishable from that produced by BSE-C agent in these mice.
Zhi et al. showed that subcutaneous tumor in nude mice (produced by injecting with pcDNA-NT5E transfected MCF-7 cells) grew in a more rapid fashion when compared with parental MCF-7 cells produced subcutaneous tumor.
The initial cross between an AR male mouse and SJL/J female mice produced F1 progeny with a disease incidence of 32% (12 of 37), suggesting a possibly dominant phenotype.
However, knocking in FGFR3 with achondroplasia mutation in cartilage of transgenic mice produced a small mouse with short bones, a phenotype similar to those seen in human achondroplasia [ 111].
Spleen cells from calpain multiple antigenic peptide (MAP -immunized BALB/c MAP -immunizedIFNγ upon stimulation with MAP or soluBALB/crmicetigen producedIFNγ(SWAP).
Intercross of Bcl2l2 +/− ; Nnt +/+ mice produced Bcl2l2 −/− with the expected frequency, whereas intercross of Bcl2l2 +/− ; Nnt −/− animals did not.
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