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Additionally, the BK5.EP2 mice produced much larger tumors than their wild-type counterparts.
When we measured secreted IgE levels from CD19+ B cells, CD19+ B cells from AD-induced mice produced much higher level of IgE compared to that of normal mice.
In addition, at the endpoint of the 27-month exposure, the splenic CD8 T cells from these experimental mice produced much less IFN-γ and IL-2 than the controls (Supplementary Figure 4).
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Although APPPS1 mice produce much more Aβ and accumulation starts much earlier than in Tg2576 mice [ 9, 19, 23, 30] median plaque growth rates were about 0.3 μm/week in both mouse models [ 16- 20, 31].
These studies, together with analyses of gene mutations in mice, have nonetheless produced much information on extracellular factors able to direct differentiation into particular lineages (reviewed in refs. 2, 9, 11, 12).
We have shown that all mice immunized with OVA delivered through NLC produced much higher antibody titers for all tested formulations as compared to that immunized with OVA or OVA formulated in Complete Freund Adjuvant (CFA, positive control).
Accordingly, mice deficient in autophagy related gene 5 (Atg5) or pDCs treated with autophagy inhibitors produced much lower amount of IFN than wild type mice and only responded to replication competent viruses (Lee et al. 2007).
Neither action has produced much.
Adoptive transfer of sera containing DNCB-specific Abs from DNCB-treated mice produces a much stronger hypersensitivity skin reaction than the adoptive transfer of lymph node cells from the same donors.
In vitro assays indicated that isolated IsdB specific splenocytes from immunized mice produced abundant IL-17A, much less IFN-γ and no detectable IL-4.
The mouse heart beats much faster than the human one, and the mouse heart myosin produces much higher contraction speed [ 7].
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