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In our model, mice presented variable levels of antigen specific antibodies and the higher amounts did not necessarily correlate with protection from challenge.
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Epidemiological studies presented variable findings.
Consistent with the phenotype observed in patients with kidney disease, our Trpc6 transgenic mice presented albuminuria in adult male mice with variable penetrance observed in the analyzed transgenic lines.
In wild-type mice, while the same two PrPSc patterns, 87A-like and ME7-like, were observed in RIII and C57BL mice on primary isolation, the number of mice presenting each pattern was variable between UK-1 and UK-2 in each mouse line.
No anatomical abnormalities were observed in E16.5 Hspy/+ Whi/+ embryos (n=5), other than the anomalies present in Chd7 Whi /+ mice with variable penetrance (cleft palate, choanal atresia, heart defect; data not shown).
However, this phenotypic feature was only present in a small proportion of Col2-Tgrdw mice, suggesting variable expressivity.
Continuous variables presented as medians with interquartile range; categorical variables presented as n.
The surgical techniques necessary for the implantation of blood pressure transmitters in inbred mice of variable body weight had been established and standardized prior to the present study.
Briefly, mice were put in the mouse enclosures and acclimated for 2 min. Six trials of 40-ms 120 dB white noise bursts were then presented with a variable intertribal interval.
Continuous variables presented as the median (interquartile interval) and categorical variables presented as the percentage.
Continuous variables presented as the mean ± standard deviation; categorical variables presented as the percentage.
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