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Experiments were performed 10 weeks after induction of uremia, when CKD mice presented severe uremia and Apo-E KO mice presented marked atherosclerosis (data not shown).
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However, when individual mice within each strain were considered, a tendency was seen for mice presenting severe respiratory distress, particularly those mice with the highest clinical score, to mount the highest levels of matrilin-1-specific antibodies.
Nevertheless, the mouse presented severe burns on the head and both forelimbs.
The mouse presented severe burns on the head and both forelimbs, it was hospitalized and approximately 2 months after surgery burns were resolved.
These double deficient mice present severe clinical manifestations of muscular dystrophy [4], [5].
Moreover, we have shown that APP mice present severe social learning and recognition deficits, that relies mainly on integrity of the MeA.
Afterwards, although 5-LO−/− mice presented less severe lethality when compared to WT mice, progressive lethality did occur.
With respect to liver morphology, GalN/LPS-treated mice presented with severe liver congestion, inflammation and massive necrosis as previously reported [ 8].
In the histological examination, lungs from WT mice subjected to high VT ventilation presented severe injury with the presence of mixed inflammatory infiltrates (neutrophils and alveolar macrophages) in the interstitial and alveolar spaces, edema, and thickening of the alveolar walls, and a lung injury score of 0.7.
Most mice in the WT and the mutant groups presented severe clinical signs associated with septicemia, such as depression, swollen eyes, weakness and prostration during the first 24 h post-inoculation (pi).
In contrast, in the B6 background heterozygous mgΔloxPneo mice were asymptomatic at 3 months of age, whereas by 9 months they presented severe alterations indistinguishable from those of 129/Sv heterozygotes at the same age.
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