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B1KO had a significant reduction in sCr at all times analyzed, meanwhile B2KO mice presented lower sCr values only at 4 and 24 h.
Furthermore, Jnk2-deficient and Wnt4 hemizygous mice presented lower numbers of HPCs in their bone marrow, and Jnk2-deficient HPCs showed increased rates of apoptosis.
In agreement, 5-LO deficient (5-LO−/−) mice presented lower lethality rates compared to WT mice.
Tibialis anterior of control mice presented lower triglyceride content than the soleus.
Concerning the fibre size variance coefficient, wild-type mice presented lower values when compared to mdx mice.
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However, liver extracts of Epm2a-/ mice already presented lower proteasomal activity and higher induction of ER-stress markers than control mice.
Interestingly, Sei1-null mice present lower number of islets, decreased β-cell area, impaired insulin secretion, and glucose intolerance.
In fact, we have previously shown that DNP mice, similarly to CR mice, present lower titers of circulating glucose and insulin [4].
In contrast, Hs578T, xenografted in mice, presented a lower angiogenic index, expressed VEGF, but did not express TGFα.
In addition, newborn TRF2 Δ/Δ K5-Cre mice presented a lower body weight than their wild-type counterparts and died immediately after birth (Fig. 1B).
Pull-down and Western blot analysis showed that O kidneys of FTI-treated mice presented significantly lower Ras activation than kidneys of vehicle-treated animals).
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