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Several lessons can be learned from the mice presented in Table 1.
The Lck Cre ringless mice in our 2013 Immunity report are indeed the same as the Rc3h1 Tringless mice presented in the current study.
Ophthalmic examinations of mice presented in Figs. 3 and 4 revealed only sporadic ocular abnormalities, none of which were related to group or treatment.
Consistent with the findings from DIO mice presented in Fig 5B/5C, VAT from Rag1 −/− mice showed significantly reduced expression levels of M1 cytokines and chemokines (TNF-α, IL-1, IP-10 and MCP-1) after receiving donor CD4+ T cells.
Taken together with the finding that cutaneous adnexal tumors were also found in three other C57BL/6-Tg (ITF-TMEM207) mouse lines, we think that enforced TMEM207 expression is directly associated with cutaneous adnexal carcinogenesis in the transgenic mice presented in this study.
The PET imaging and biodistribution data of VCaP-bearing nude mice presented in this study show that peptide receptor-based targeting using Ga-AMBA for the GRPR is superior to metabolism-based targeting using F-FCH for detection of PC xenografts in nude mice.
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All these data suggest that RhoE could be involved in motoneuron diseases and that the RhoE mutant mouse presented in this work could be a useful animal model for these diseases.
The transgenic mouse presented in this paper contains, in addition to all mouse Cyp2c enzymes, human CYP2C18 and CYP2C19.
Neither STI1TGA nor STI1−/+ mice presented deficits in acquisition or retrieval of spatial memory in the MWM.
Heterozygous mice were normal, while homozygous knock-in mice presented abnormalities consistent with those observed in the patient.
Our analysis determined that Mecp2-null mice presented macroscopic abnormalities in the colon.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com