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Neuromuscular examination and rotarod experiments revealed that patDp/+ mice possess normal motor coordination (Table S1).
In an evaluation of the underlying causes of decreased exploratory activity in patDp/+ mice, motor tests showed that patDp/+ mice possess normal motor coordination.
To study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (DAT+/−), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition.
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In addition, infected RAG2−/− mice that possess normal monocyte and neutrophil compartments did accumulate fewer IRBC than WT mice (Figures 1 and S2).
However, SIRT6-deficient mice possess a normal lymphocyte complement prior to the onset of apoptosis [ 18].
For example, mice completely deficient in DNA-PKCS can join signal end intermediates in V(D J recombination, and ES cells from such mice possess a normal level of resistance to IR (Gao et al, 1998b; Taccioli et al, 1998).
Embryonic fibroblasts isolated from B9d1-null mice possess structurally normal cilia but still demonstrate reduced Hh signalling capacity, and a number of proteins that normally localise to cilia failed to localise to B9d1-deficient cilia (Dowdle et al., 2011).
Previous studies have shown that Fz3 is involved in PCP signaling in the context of axon guidance [64] and that Fz3-deficient mice, whilst possessing normal numbers of DA neurons, have no nigrostriatal pathway [57], [58].
We also determined that most of the SOD1 protein in spinal cords of the G37R/WT mice possessed the normal intramolecular disulfide bond, indicating that the excess burden of WT SOD1 did not greatly alter the ability of the system to properly process both WT and mutant SOD1 (Supplementary Material, Fig. S3).
We can conclude that reconstituted C57BL/6 ZAP-/ mice possess T lymphocytes with normal in vivo functional properties, enabling them to respond to an OVA DNA vaccine and rapidly reject fully MHC-mismatched BALB/c skin grafts.
Finally, I identified that Mcm hypomorphic mice possess a unique gender bias phenotype.
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