Utilization of thy1.2YFP16 transgenic mice 26, 27 permitted us to observe axonal and neuromuscular synaptic degeneration within the same, reanaesthetized animals at several time points.
All oral glucose administrations were conducted in a commercially available gustometer (Davis MS160-Mouse; DiLog Instruments), which permitted us to monitor the number of licks taken by each mouse.
The mouse models presented in this study permitted us to visualize the progression of tau pathology in the presence or absence of widespread Aβ plaques, therefore closely recapitulating conditions occurring early in AD.
Finally, grafting of epidermis reconstituted in vitro on dermal substrates to SCID mice permitted sustained monoclonal antibody delivery into the bloodstream to be achieved.
Indeed, these mice permitted valuable studies on T cell development and immune responses [1], [2], [3].
The development and characterization of M-CyldΔ9 mice permitted the functional evaluation of CYLD in the myelomonocytic lineage and revealed an anti-inflammatory element of the functional profile of this molecule.
In the developing retina (E14), Neurog2-d4Venus mice permitted better visualization of differentiating cells (Movie S2, Fig. 7A) than Gadd45g-d4Venus mice, and apically dividing d4Venus+ cells (21.2% of the total apically located M-phase cells) (Fig. 7B,C), as well as occasional non-surface-dividing d4Venus+ cells (Movie S2), could be clearly observed.
Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and metabolomics.
Thus, Psen cDKO mice permit assessment of direct consequences of presenilin inactivation in excitatory pyramidal neurons of the adult cerebral cortex, where presenilins are normally expressed highly and AD pathogenesis occurs.
This is in contrast to studies with [124I]FIAU in mice, which required 16 to 24 hours to obtain optimal images.[10] The difference is likely due to the much greater size of humans compared to mice, permitting easier distinction between localized sites of infection and other sources of signal.
