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Figure 1B also shows the APP/PS1 KI and WT mice performance on the 1 cm beam (APP/PS1 KI mice had 20.28 ± 1.54 foot slips compared with 17.92 ± 1.00 foot slips for WT mice).
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As previously demonstrated, an unsupervised hierarchal clustering algorithm can correctly sort the CGG KI mouse performance on a number of behavioral tasks into appropriate repeat-length subgroups.
CTB-SAP lesion caused a significant effect on mice performance at the grid walk test (one-way ANOVA: F2,27 = 35.616; P = 0.000; Figure 5).
The scientists simply compared older mice's performance on standard laboratory tests of spatial memory after these mice had received infusions of plasma (the cell-free part of blood) from young versus old mice, or no plasma at all.
"We were astonished that not only did this improve the mice's performance on the memory tests, but their performance was comparable to that of young mice," said Dr. Pavlopoulos.
The selective GluR5 antagonist LY382884 was locally injected into the BLA of wild-type mice and performance on the EPM was evaluated.
Testing was considered complete when WT mice reached asymptotic performance (one error on T4 and T5; 10 training days).
Mouse performance is also spot-on – don't think this will help my Unreal Tournament game though.
Cntnap2−/− mice and patDp/+ mice show enhanced performance on a gross motor task, the accelerating rotarod (Nakatani et al., 2009; Peñagarikano et al., 2011); but the other three mouse models do not (Shahbazian et al., 2002a; Kouser et al., 2011; Tsai et al., 2012).
In the N171-82Q malel, mice mice show poorer performance on the rotarod than female mice [37].
From the age of 18 months, p23-ST1 mice displayed poor performance on the rotarod running test compared to control mice (Fig. 4) suggesting a decline in motor coordination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com