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"Although our investigations were conducted in mice, our data may have implications for diet and reproduction in humans," said David Gardner, scientific director of the Colorado Centre for Reproductive Medicine in Englewood.
Given CD8+ T-cell epitopes from E9L were also identified in humans and mice, our data suggested that F8L/E9L may be a dominant pox viral protein for CD8+ T cell responses, and may be considered as a target when designing vaccines that target pox-specific T cell responses.
In contrast to findings in mice, our data show that HOXA9 has modest effects on the proliferation and differentiation of primary human CD34+ cells.
Whereas conventional B2 cell differentiation is affected in Gfi1-deficient mice, our data suggest that B1 cell differentiation might be preserved (Rathinam and Klein, submitted).
First, unlike Nestin-GFP mice, our data suggests that only postmitotic newborn neurons, not proliferating progenitor cells, are labeled in GAD67-GFP mice.
Although the genotyped panels of SNPs were not dense enough to support conclusive evaluation of LD structure in CD-1 mice, our data provide an estimation of LD structure sufficient to evaluate suitability for genetic studies.
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Compared to genic piRNAs in mouse, our data suggests humans have a higher proportion of genic piRNAs: only ~2% of piRNAs are genic in mouse adult testis [ 11].
Despite these results in the mouse, our data support an important role of AGPAT6 in bovine mammary and very likely in TAG synthesis, as previously discussed [ 19].
Considering that both genes are located to the middle of the domain and that all the imprinted genes in this domain are co-ordinately regulated by a single imprinting centre in the mouse, our data strongly suggests that the whole KCNQ1 domain lacks genomic imprinting in marsupials.
Morphological results suggested that FPI mice with IE showed less dead cells as compared to FPI mice without IE. Our data also suggested a new dimension for the factors influencing FPI recovery.
Indeed, when the Ets1 transgene is expressed in the basal compartment of the epidermis (including epidermal stem cells) using a keratin 5 (K5) tTA transgenic line, no phenotype is evident in adult BT mice (our unpublished data).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com