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Conversely, in mast cell-depleted mice only few single ruthenium red-positive mast cells were detected (data no shown).

While MCK-tTA RNF5 DTg animals exhibited histopathological changes similar to those observed in the β-actin expressing RNF5 mice, only few animals exhibited these phenotype within the same time frame seen for rtTA RNF5 DTg mice (6 wk).

We have demonstrated that B cells that are engineered to express the MOG peptide p35-55 on MHCII interact with MOG-specific CD4+ 2D2 T cells in a process that eventually results in the deletion of naïve T cells, as in the periphery of these mice only few MOG-specific T cells can be found.

Whereas i.v. immunization elicited sterile protection in nearly all the mice, only few of the i.d.- or s.c.-immunized mice (13 20%) were protected (Table 1).

In APP48 mice only few dendritic threads exhibited AβN3pE at 3 months of age whereas at 18 months of age a significant number of AβN3pE-positive inclusions was observed as shown previously [ 16].

Similar(55)

PbΔ b9 elicits long-lived protective immune responses in mice and only few breakthrough blood infections occur in mice, albeit less than were observed with PbΔ p52Δ p36 GAP sporozoites (Annoura et al., 2012).

Severe insulitis (>50% of the islet infiltrated) was rarely observed in the SGF NOD mice, and only few intact islets were found in the SSTD NOD mice.

In tubules of 25-day-old control mice only very few SC displayed signs of immaturity and tight junctions restricting permeation of lanthanum were seen between SC located at the base of the epithelium (Figure 2E).

Although CRYs and the other circadian clock components have been extensively studied in the higher vertebrates such as mice, only a few model species have been studied in the lower vertebrates.

Apparent brain histological abnormality was hardly detected in Hp/− mice; only a few mice showed a very small ectopic cluster of neurons migrating into the marginal zone.

In mice, only a few studies have employed it to assess ischemia and reperfusion renal injury [ 5, 6].

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