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(Having two defective genes is lethal, and mice of this kind died shortly after birth).
Aortic diameters in rats and mice of this age are, respectively, 2.6 mm [13] and 1.35 mm (S Hollenberg, personal communication).
Homozygous mice of this breeding served as controls.
The mice of this line exhibit a long asymptomatic phase, reminiscent of the disease course in ALS patients.
Four mice of group 6 developed detectable HI-antibody responses with a GMT of 48, the other mice of this group did not seroconvert (figure 1A).
Four hours post transfer the animals were infected by the s.c. route with 100 TCID50 of WNV-NY99, which is a lethal dose for mice of this age.
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Bax-deficient Ku70-null mice of the same age maintained this fat layer (Supplementary Table S2).
As van Dreunen put it, Nintendo has created "the Mickey Mouse of this generation".
Despite the absence of detectable CLDIs in mice, administration of this analog still led to significant skin pigmentation.
Therefore, due to the short life span of p53 knockout mice, application of this model is very limited.
Based on kernel density estimation of mouse-expected coverage, the average mouse contamination of this particular xenograft was 21% of the total DNA content of the sample.
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