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Exact(6)
Differences in Paneth cell function and intestinal microbiota composition in mice of differing background strain have also been described.
We therefore examined the expression of Npt2b in mammary tissue from lactating mice of differing Akt genotypes.
We intercrossed the previously described H-2Kb-tsA58 transgenic mouse (Immortomouse), which expresses a temperature-sensitive mutant of the simian virus-40 large T-antigen (tsTAg), with mice of differing Smad genotypes.
In the present study, we have crossed the Immortomouse with mice of differing Smad genotypes to generate a panel of conditionally immortalized mammary epithelial cells (IMECs) that allow us to cleanly dissect the role of the two Smads in different biological responses to TGFβ.
We also detected differences in hepatobiliary phenotypes between wild-type mice of differing strains.
The pattern of superoxide generation in response to muscle contractions was similar between fibers from the mice of differing ages and both groups showed similar rapid increases in hydroxyethidium.
Similar(54)
Interestingly, mouse models of differing severities show similar degrees of motor neuron loss, perhaps indicating that the developmental stage at which degeneration occurs is a key determinant of disease progression.
It would be interesting to investigate disease risk in inbred mice using training programs of differing volume/intensity so the effect of environmental factors (e.g. habitual exercise) can be assessed in a controlled environment.
However clinical data suggest the preoperative dose is the most important in providing prophylaxis [ 15, 16, 21, 51], and the faster rate of drug metabolism in the mouse means the effect of differing half-lives is reduced [ 44].
Thus, we used the limma software [ 31] to deconvolve the undesired effects of differing mouse ages as explanatory variables in a linear model, and we subtracted these variables from the original gene expression values.
We observed induction of differentiation by ROCKi in cells of mouse, rat, and human origin, of differing derivation and stage of maturation, thus validating the relevance of the observations across species.
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