Mice were maintained as hemizygotes by crossing transgenics to wild-type mice of a B6C3F1/J background.
Researchers at the Wistar Institute in Philadelphia found that mice of a type first bred several decades ago and used to study autoimmune diseases were able to regrow healthy heart tissue with little scarring after serious heart damage.
In his early experiments, Medawar injected embryonic mouse donor cells into mice of a different strain, rendering the recipient mice tolerant to future grafts from the donor and not third-party strains [16].
We found that the combination of M147L and E627K on PB2 protein was responsible for the enhanced viral replication ability and increased virulence in mice of a mouse-adapted H9N2 virus (Wang et al., 2012b) (see Table 3).
We tested the immunogenicity in mice of a recombinant fusion protein (gp41HA) consisting of the ectodomain of the HIV-1IIIB envelope glycoprotein gp41 fused to a fragment of the influenza virus HA2 hemagglutinin protein.
Medawar did not immediately appreciate the link to Owen's work, but when he saw the connection, he decided to inject fetal mice in utero with tissue from mice of a different strain.
To try to exploit this phenomenon as a potential treatment, Datta injected large amounts of the peptides into young female mice of a strain prone to succumb to SLE.
Researchers have pinpointed the exact mix of microbes required to cure mice of a chronic infection by a hard-to-treat bacterium that causes bloating, pain, and diarrhea in people.
Previous work by our lab demonstrated that repeated exposure to WBV using protocols that model those used clinically, induces intervertebral disc (IVD) degeneration and osteoarthritis-like damage in the knee of skeletally mature, male mice of a single outbred strain (CD-1).
We provide data for learning by normal C57BL/6 mice of a repeating sequence of 12 nose poke responses, first, via the observation of increases in reaction times when repeated sequence is replaced by random sequence, and, second, by analysis of behavior during transfer trials in which one sequential element is discretely replaced by a new item.
In the present study, wild-type and GalR1−/− mice of a C57BL/6J genetic background were used.
