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Semi-quantitative pathological analysis was performed on knee joints and showed that synovial inflammation and bony erosion were significantly reduced in tacrolimus-treated arthritic mice compared to mice not treated with tacrolimus (P <0.05 and P <0.05, respectively).
Intracerebral 5 mM pre-administration of ceftriaxone, cefazolin, indomethacin and ketoprofen, which inhibit PGE2 elimination across the BBB in mice not treated with LPS [ 6], did not significantly inhibit PGE2 elimination in LPS-treated mice (Table 3).
Control immature oocytes were recovered from preovulatory follicles of superovulated mice not treated with cilostazol.
Cochleas of Fgfr3-iCre-ERT2 Ai14 Fgfr3-iCre-ERT2 Ai14 Fgfr3-iCre-ERT2 Ai14P imiceoreactivity (data not shown).
This improved recall also occurred when brain-damaged mice not treated with the HDAC inhibitor were placed in an enriching environment.
In lab experiments, wounds on mice treated with printed skin cells healed in three weeks, versus five weeks for mice not treated with the printed skin.
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As with the 3-day assay, oral DE-71 administration had no effect on any of the estrogenic parameters measured in BALB/c mice (data not shown); C57Bl/6 mice were not treated orally.
Since TRPV4 KO mice were not treated with pharmacological stimuli, baseline parameters were simply re-recorded in the same mice.
The A/J mice were not treated but were included to monitor the efficacy of the minipumps in raising plasma leptin in B6 mice.
Since the mice were not treated with the medications, it is difficult to assess whether the microRNAs would have a benefit beyond that what is achieved by conventional post-heart attack medications.
Control mice were not treated but handled daily.
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