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Another important issue that one has to consider in the development of a vaccine for RA is that the results conducted on mice needs to translate to humans.
The role of Mc1r and agouti genes in effecting such pigment switching or modulation in spiny mice needs to be studied in detail.
Whether the presence of Leu226 in the HA of these H9N2 viruses is associated with host adaptation in mice needs to be investigated further.
Whether this difference in proliferation and/or migration in vivo is also present in p524, p509 or p530-expanded CD4+CD25+ T cells when transfused into NOD mice needs to be elucidated in further studies.
The proto-oncogenic Neu in these young mice needs to be activated by a deletion in its extracellular domain, so the growth signals that will drive cancer formation are not evident at this early stage [39].
Although the signaling pathway regulated by SIRT1 in HD mice needs to be further addressed, our results support developing STACs as therapeutic agents for HD.
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The long-term effects in mice need to be measured and it must be determined whether effective amounts of glutathione or other therapeutic drugs can pass through the human skull.
During the second task, however, when the mice needed to learn the location of the hidden reward, the maps in the deep sublayer were significantly more stable, and less dynamic, than in the first task.
So these results in germ-free mice need to be confirmed in humans.
The mice needed to take the drug in advance of a heart attack in order for it to be effective.
All tested mice needed to be fasted overnight (12 h) during the experiment to avoid the absorption of CUR being influenced by food.
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