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Invasion of inflammatory cells and hitherto the rest of the wound healing cascade is inhibited in plasminogen or uPA deficient mice, most likely by the inhibition of MMP activity.
Present findings are consistent with the conclusion that spinal cord-projecting axon terminals of A11 DA neurons are activated by opioids in both male and female mice, most likely through a dis-inhibitory mechanism.
After tracking down the mice in the wild in Kenya, the researchers discovered that, indeed, the spiny mouse's skin is 20 times weaker than the skin of lab mice, most likely because it has larger hair follicles.
Mechanistic insights into this phenotype suggest that adiponectin deficiency enhances tumor growth in mice most likely by reducing macrophage infiltration.
No positive effect on RCT was found in CETP transgenic mice, most likely due to the observed decrease in plasma CETP mass.
Interestingly, intracellular FACS staining revealed higher frequencies of IFNγ+ T-cells in old mice, most likely attributable to the expanded effector/memory CD4+ T-cell population (Fig. 5).
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However, disruption of other PDE4D complexes in the PDE4DKO mouse most likely contributes to the development of the cardiac phenotype.
The increased incidence of DP cells in influenza-infected Cd59a /– mice compared to WT mice is most likely a consequence of the more profound inflammatory response to influenza virus observed in these mice.
The moderate increase in BrdU-positive cells within the 24-h survival group of bim−/− and puma−/− mice, although not statistically significant from wt mice, is most likely explained by a survival effect rather than an enhanced proliferation rate.
That from NOD mice is most likely inducing diabetes since the colonization of these mice with a microbiota from non-type 1 diabetic mice prevented the incidence of diabetes in germ-free NOD mice.
While it has been shown that the deletion leading to this truncation also causes haploinsufficient loss of 23 nearby genes (Gentry and Venkatachalam, 2005), a careful analysis of the phenotypes observed in p53+/m, p53m/− p53+/− and p53−/− mice suggests that the premature ageing phenotypes in p53+/m mice are most likely related to the p53 truncation (Vijg and Hasty, 2005).
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