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Many in vivo studies carried out on rat and mice models indicated inhibitory effects of fumaric acid on carcinogenesis of different origins.
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In vivo studies on Ehrlich's ascites carcinoma (EAC) mice model indicated that Se-CurNPs significantly reduced the tumor load and enhanced the mean survival time (days) of tumor-bearing EAC mice.
Furthermore, in vivo BALB/C nu/nu mice model indicated that ulinastatin effectively reduced recurrence after resection of hepatic metastases from colon cancer.
Transcription analyses of in vitro stress, macrophage infection, and mouse models indicated that virB positively regulates vjbR, a quorum sensing (QS) regulator that functions in a cell-dependent manner.
Research in mouse models indicated that antibodies to U1, C1 and J1 CII epitopes are arthritogenic and their levels correlate with development of chronic arthritis [ 17, 18].
Together, the data from transgenic mouse models indicated that each of the EDG family of LPA receptors is sufficient to induce invasive and metastatic tumours when aberrantly expressed in mammary epithelial cells.
The low injection dosage and high efficiency of NZ2114 in the mice model indicates that the drug resistance will be rare and it is suitable for the clinical treatment of S. suis infection.
Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita.
However, the high degree of growth retardation and peri-natal mortality in IGF-I deficient mouse models indicates that it plays a critical role during this time.
Results from SMA mouse models indicate ISIS-SMNRx had a significant effect on functional and histological measures of neuromuscular health when delivered to the CNS.
However, recent findings in preclinical mouse models indicate that infusion of T-cells directed against tumor-associated auto-antigens can be associated with higher 'on target' toxicity than was anticipated on the basis of anti-tumor vaccination studies.
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